Treatments

Drug repurposing screens identify chemical entities for the development of COVID-19 interventions

Nature Communications volume 12, Article number: 3309 (2021)

Hirofumi Ohashi et al, Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment, iScience (2021). DOI: 10.1016/j.isci.2021.102367

Daniloski, Z., Jordan, T.X., Wessels, H.-H., Hoagland, D.A., Kasela, S., Legut,
M., Maniatis, S., Mimitou, E.P., Lu, L., Geller, E., Danziger, O., Rosenberg, B.R., Phatnani, H., Smibert, P., Lappalainen, T., tenOever, B.R., Sanjana, N.E., Identification of required host factors for SARSCoV-2 infection in human cells, Cell (2020), doi: https://doi.org/10.1016/j.cell.2020.10.030.

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition

Jia YuXuan YuanHang ChenShruti ChaturvediEvan M. BraunsteinRobert A. BrodskyBlood blood.2020008248.https://doi.org/10.1182/blood.2020008248

July 24, 2020 Nature

Discovery of SARS-CoV-2 antiviral drugs
through large-scale compound repurposing
Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Lars Pache,
Sebastian Burgstaller-Muehlbacher, Paul D. De Jesus, Peter Teriete, Mitchell V. Hull,
Max W. Chang, Jasper Fuk-Woo Chan, Jianli Cao, Vincent Kwok-Man Poon, Kristina M. Herbert,
Kuoyuan Cheng, Tu-Trinh H. Nguyen, Andrey Rubanov, Yuan Pu, Courtney Nguyen,
Angela Choi, Raveen Rathnasinghe, Michael Schotsaert, Lisa Miorin, Marion Dejosez,
Thomas P. Zwaka, Ko-Yung Sit, Luis Martinez-Sobrido, Wen-Chun Liu, Kris M. White,
Mackenzie E. Chapman, Emma K. Lendy, Richard J. Glynne, Randy Albrecht, Eytan Ruppin,
Andrew D. Mesecar, Jeffrey R. Johnson, Christopher Benner, Ren Sun, Peter G. Schultz,
Andrew I. Su, Adolfo García-Sastre, Arnab K. Chatterjee, Kwok-Yung Yuen & Sumit K. Chanda