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The Problem

Opioid overdose deaths remain a major public health crisis in the US and worldwide, driven largely by fentanyl and other synthetic opioids. After peaking at nearly 110,000 US overdose deaths in 2023, provisional CDC data show approximately 69,973 drug overdose deaths in 2025 — a 14% decline from 2024 and the third consecutive annual drop. Deaths involving opioids fell to an estimated 44,564 in 2025, down from 55,296 in 2024, with synthetic opioids like fentanyl dropping from 48,913 to 38,084 deaths. Despite this progress, opioids still account for roughly two-thirds of all overdose deaths, and fentanyl remains the single largest driver of the crisis.

An estimated 4.0 million Americans have opioid use disorder (OUD), yet only about 15.7% — roughly 623,000 people — receive medication treatment, leaving a substantial treatment gap. Our site provides telemedical solutions for the diagnosis, prevention, and treatment of opioid use disorder

Neuro-metabolic theory for Opioid Use Disorder

Prevention of Opioid Use Disorder

Prevention can be accomplished by utilizing risk analysis.

Predictive models have been developed to determine the propensity for opioid use disorder as well as its diagnosis.  The predicted propensity value can be used to target high risk  groups with evidence based interventions as well as personalize individual intervention programs .  Start Analysis of your risk factors Now or help analyze someone else’s.

Diagnosis and treatment of opioid use disorder

 

Opioid addiction therapy includes :

Literature and Related Sites