APP recognizing senescent CD8 T cells have been proposed to be a strong causal factor for the initiation or accelerated progression of sporadic Alzheimer’s Disease – LOAD.
ApoE4 carriers are primed to develop Senescent CD8 T cells and Altered Monocytes that travel from the peripheral blood and into the brain. These cells have a been demonstrated to be pathological initiators of microglia DAM activation, Astrocyte activation and senescence, oligodendrocyte precursor apoptosis, and Oligodendrocyte dysfunction in Mice. Human studies suggest that these T Cells serve as biomarkers of preclinical and early clinical AD.
Epigenetic dysregulation in Alzheimer’s disease peripheral immunity: Neuron
Immune dysfunction in Alzheimer disease | Nature Reviews Neuroscience
Neuroimmune contributions to Alzheimer’s disease: a focus on human data | Molecular Psychiatry
CSF-Derived CD4+ T-Cell Diversity Is Reduced in Patients With Alzheimer Clinical Syndrome – PMC
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