Tools for Diagnosing the Solitary Lung Nodule :
Liquid Biopsies : circulating tumor methylated DNA : Pulmoseek/PanSeer, antibodies to tumor associated antigens: CAGE, p53, MAGE A4, SOX2, HuD, GBU4-5, NY-ESO-1 , Serum levels of : CEA125, LASA (lipid associated sialic acid), LG3BP, C163A, plasma mi-RNA profiles (miR-1268b and miR-6075), 14-miRNA signature profile, exosomes with miRNAs, metabolomics, 21 mRNA bronchial transcription profiles /Percepta)
CT Scans with and without enhancers . (ie. Iodine, others)
PET Scans with Immuno Labeling, FDG, or other tracers.
Needle Biopsies via Electromagnetic Navigational Bronchoscopy vs Transthoracic Needle biopsy
Surgical Biopsies or Wedge Resections using Video Assisted Thoracotomy or Robotic assisted minimally invasive surgery.
Bronchoalveolar lavage fluid cytometry
Sputum Cytometry.
Diagnoses :
Non small cell lung carcinoma
Adenocarcinoma (mucinous, and various grades, including bronchoalveolar carcinoma)
Squamous cell carcinoma
Undifferentiated lung cell carcinoma
Small cell lung carcinoma (see mir-
Metastatic lung cancer