Stress Granule Model

The Combined Stress Granule – Exosome Model

Circular RNA as the key drivers of stress granule RNA and protein content.

Exosomes carry of RNA (circRNA, miRNA, mRNA, and lncRNA) and Protein that originated from Stress Granules . Exosomes with circRNA communicate with the Extracellular Space and Other cells of the immune system for pathological or therapeutic purposes.

Neuron First Model – Premature and halted Neurogenesis regulated by ROS (Reactive Oxygen Species) and altered synaptic protein utilization.

Activated Microglia First Model causing chronic neuroinflammation.

Notch and PI3/Akt pathway dysfunctions in Astrocytes or Microglia as a cause of Alzheimers Disease

Astrocyte First Model based on Activated or Stressed Out Astrocytes

Gaba and Hydrogen peroxide production from Astrocytes

Astrocyte transriptomic changes in AD

Oligodendrocyte First Model based on Senescent, infected, or injured Cells

Vaccinations reduce the risk of developing Alzheimer’s by enhancing the immunophagocytic systems in the brain that help eliminate amyloid plaques.

Lithium deficiency as a contributor to Alzheimers Disease through uninhibition of GSKBeta 3 ( Glygogen Synthase Kinase 3) , Increased phosphorylation of Glycogen Synthase, Decreased production of glycogen, increased Aerobic Glycolysis, and increased ROS

The C1q based complement cascade system participates in removal of amyloid while also activating neuroinflammatory systems that cause neurodegeneration.

AD Data Initiative | AlzInsights Prize for ADRD Research

AD Discovery Portal