Biologics and small Drug Molecules

Small Molecule DrugBiological Drug
AR1001Lecanemab- anti amyloid antibody
BuntanetapSemaglutide
MastinibGonadorelin
MetforminDonanemab – anti amyloid antibody
NiolimibE2814
PMO12 – herbal formulaGantenerumab – anti amyloid antibody
Simufilam ( failed phase 3 studies)Terlomotide is a fragment derived from the human telomerase reverse transcriptase (hTERT) enzyme, specifically a 16–amino acid sequence (hTERT 611–626).
TricaprilinRemternetug is an anti-amyloid antibody developed by Eli Lilly
Valiltramiprosate – prevents oligomerization of Amyloid BetaSolanezumab selectively targets and binds to soluble monomeric forms of amyloid-beta (Aβ) peptides in the brain – from Eli Lilly
Wujia Yitzhi

small Extracellular vesicles with exerkines, miRNA, AAV vectors, and circRNA

Stem Cells – Various Types

Genetically engineered microglia with trans skull brain injection

Intracisternal CSF injection of AAV vectors with ApoE2 christchurch and anti APOE4 miRNA

KCTD20 gene inactivation in glutamate excitatory neurons