{"id":8713,"date":"2021-08-08T20:14:11","date_gmt":"2021-08-09T03:14:11","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=8713"},"modified":"2021-09-23T21:40:41","modified_gmt":"2021-09-24T04:40:41","slug":"viral-structural-or-non-structural-proteins-nsps-encoded-by-the-large-rna-genome","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/covid-19-treatments\/viral-structural-or-non-structural-proteins-nsps-encoded-by-the-large-rna-genome\/","title":{"rendered":"Viral structural or Non structural proteins (NSP\u2019s) ."},"content":{"rendered":"\n<ul class=\"wp-block-list\"><li><strong>Viral RNA polymerase (nsp12) replication\/transcription Enzyme inhibitors<\/strong>&nbsp;<strong>or g\/sg RNA terminators\/mutators:<\/strong>&nbsp;iv&nbsp;<strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa2007016?articleTools=true\" target=\"_blank\">Remdesivir<\/a>&nbsp;<\/strong>= delayed terminator from&nbsp;<a href=\"http:\/\/www.gilead.com\/\">Gilead&nbsp;<\/a>( FDA approved ) .&nbsp;<a href=\"https:\/\/www.bmj.com\/content\/370\/bmj.m3379\">Not recommended by the World Health Organization.<\/a> <\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Viral Spike Protein Receptor Binding Blockade \/Neutralization :&nbsp;<\/strong><a href=\"http:\/\/www.lilly.com\/\">Eli Lill<\/a>y\u2019s monoclonal antibody-<a href=\"https:\/\/medicalxpress.com\/news\/2020-08-clinical-trial-antibody-treatment-covid-.html\">LY-CoV555<\/a>&nbsp;and&nbsp;<a href=\"http:\/\/www.regeneron.com\/\">Regeneron<\/a>&nbsp;-Roche 2 monoclonal antibody combination have FDA Emergency Use Authorization for use in early infection (prior to development of endogenous antibodies) in high risk patients.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>ProTac<\/strong>&nbsp;molecular medicines contain VHL like sequence peptide tags chemically linked to a molecular agent with viral or host protein binding capabilities. ProTACs target the protein (viral nsp\/structural proteins\/ or complicit host proteins ) to E3 ubiquitin ligase which ultimately result in proteolysis by the Cytosolic Proteosome.<\/li><li><a href=\"https:\/\/www.telemedical.com\/wordpress\/covid-19-treatments\/experimental-viral-targeted-treatments\/\">Experimental Treatments<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Unknown or&nbsp;<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.0c00052\">Multiple mechanisms&nbsp;<\/a>of action<\/strong>&nbsp;:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/sorrentotherapeutics.com\/research\/covid-19\/salicyn-30\/\">Salicyn-30,<\/a>&nbsp;Niclosamide (?glucose transporter inhibitor, STAT 3 Inhibitor, Beclin-1 stabilizing, hydrogen ionophore\/lysomotropic )<\/li><li><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2773108\">Fluvoxamine \u2013 antiviral effects via its lysosomotropic properties,<\/a><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2773108#jpc200006r24\">24<\/a>&nbsp;modulation of the effect of IRE1 effects on autophagy,<sup><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2773108#jpc200006r25\">25<\/a><\/sup>&nbsp;and SSRI inhibition of platelet activation- or&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33364957\/\">activation of the sigma 1 Receptor.<\/a>, and\/or anti-inflammatory properties,  i<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8094534\/\">nhibition of virus release via the lysosomal exocytosis pathway by blocking acid sphingomyelinase<\/a> .<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><a href=\"https:\/\/www.uchealth.org\/today\/zinc-could-help-diminish-extent-of-covid-19\/\">Zinc&nbsp;<\/a>+&nbsp;<a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1001176\">zinc ionophores<\/a><\/strong>: Zinc with drug X, quercetin from honey, ECGC from green teas, zinc + chloroquine.<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Debunked Treatments : Zinc, Hydroxychloroquine, tocilizumab (<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2028836\">one study showed no benefit in reducing death<\/a>)\/<a href=\"https:\/\/www.discovermagazine.com\/health\/who-gets-sickest-from-covid-19\">IL-6 inhibitor<\/a>,   <a href=\"https:\/\/www.covid19treatmentguidelines.nih.gov\/tables\/table-2c\/\">Ivermectin<\/a> <\/h3>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><a href=\"https:\/\/www.covid-trials.org\/\">Global Coronavirus Clinical Trial Tracker<\/a><\/strong><\/h4>\n\n\n\n<h4 class=\"wp-block-heading\"><strong><a href=\"https:\/\/cdcn.org\/corona\/\">CORONA \u2013 Covid-19 Registry of off label and new agents.<\/a><\/strong><\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.telemedical.com\/wordpress\/covid-19-treatments\/references\/\"><em>References<\/em><\/a> <\/h3>\n","protected":false},"excerpt":{"rendered":"<p>Viral RNA polymerase (nsp12) replication\/transcription Enzyme inhibitors&nbsp;or g\/sg RNA terminators\/mutators:&nbsp;iv&nbsp;Remdesivir&nbsp;= delayed terminator from&nbsp;Gilead&nbsp;( FDA approved ) .&nbsp;Not recommended by the World Health Organization. Viral Spike Protein Receptor Binding Blockade \/Neutralization :&nbsp;Eli Lilly\u2019s monoclonal antibody-LY-CoV555&nbsp;and&nbsp;Regeneron&nbsp;-Roche 2 monoclonal antibody combination have FDA Emergency Use Authorization for use in early infection (prior to development of endogenous antibodies) in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8281,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8713","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/comments?post=8713"}],"version-history":[{"count":0,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8713\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8281"}],"wp:attachment":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/media?parent=8713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}