{"id":8696,"date":"2021-08-08T19:17:38","date_gmt":"2021-08-09T02:17:38","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=8696"},"modified":"2021-08-08T22:03:28","modified_gmt":"2021-08-09T05:03:28","slug":"experimental-host-targeted-treatments","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/covid-19-treatments\/experimental-host-targeted-treatments\/","title":{"rendered":"Experimental Host Targeted Treatments"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\"><strong>Fusion Peptide activating protease (cellular host\u2019s TMPRSS2) inhibitor<\/strong>:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a rel=\"noreferrer noopener\" href=\"https:\/\/covid19immune.com\/articles\/camostat\" target=\"_blank\">Ca<\/a><a rel=\"noreferrer noopener\" href=\"https:\/\/en.wikipedia.org\/wiki\/Camostat\" target=\"_blank\">mostat<\/a>&nbsp;by Ono Pharmaceutical<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;Innate or Adaptive Immune System Modulators<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Dexamethasone<\/strong>\u00a0for stage 4 or greater COVID-19 Infection (Patients requiring a ventilator or in ICU) Anti-inflammatory via agonist of the cortisol receptor.<\/li><li><strong>Nebulized interferon beta 1<\/strong>\u00a0enhances innate antiviral immunity but interferon alpha\u00a0<a href=\"https:\/\/www.cell.com\/pb-assets\/products\/coronavirus\/CELL_CELL-D-20-00767.pdf\">increases ACE-2 receptor expression<\/a>\u00a0and is an indicator of severe progression of disease.<\/li><li><a href=\"https:\/\/www.precisionvaccinations.com\/vaccines\/mk-7110-covid-19-therapeutic\">Merck\u2019s MK-7011\/SACCOVID\/CD25Fc<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Inhibitors of Cytokine Storm\/Immune Hyperactivity<\/strong>&nbsp;, Inflammation, or Netosis:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>GM-CSF inhibitor<\/strong>&nbsp;<a href=\"https:\/\/www.clinicaltrialsarena.com\/comment\/humanigens-and-kiniksas-anti-gm-csf-antibodies-likely-to-garner-a-place-for-nonventilated-covid-19-patients\/\">(Humanigen\u2019s lenzilumab and Kiniksa Pharmaceuticals\u2019 mavrilimumab<\/a>&nbsp;)<\/li><li>Cortisol, CCR3 Inhibitor, TNF-alpha Receptor Blocker,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28261486\">&nbsp;Complement C5inhibitors + CD14 blockers will inhibit Toll Receptor Signaling&nbsp;<\/a>, Immune rejection suppressors, Jak1\/Jak2 inhibitors and inhibitors of endocytosis (&nbsp;<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)30304-4\/fulltext?rss=yes#articleInformation%5C\">bari<\/a>ci<a href=\"https:\/\/www.thelancet.com\/journals\/laninf\/article\/PIIS1473-3099(20)30132-8\/fulltext\">tinib<\/a>) , and others<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Other pending <strong>vaccines for antibody mediated or CD8 killer cell based immunity.<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li>Astrazeneca \u2013&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/COVID-19_vaccine\">Oxford University<\/a>\u2013&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2608-y\">ChAdOx1-nCoV-19<\/a>&nbsp;(&nbsp;<a href=\"https:\/\/www.independent.co.uk\/news\/health\/covid-vaccine-oxford-coronavirus-study-b1760172.html\">70%<\/a>&nbsp;to 90%&nbsp;<a href=\"https:\/\/www.independent.co.uk\/news\/health\/covid-vaccine-oxford-coronavirus-study-b1760172.html\">effective<\/a>&nbsp;with 2 shots 1 month apart )<\/li><li><a href=\"https:\/\/www.gsk.com\/en-gb\/media\/resource-centre\/our-contribution-to-the-fight-against-2019-ncov\/\">Glaxo<\/a>&nbsp;adjuvant with Sanofi, Clover, or Medicago Antigen<\/li><li><a href=\"https:\/\/en.wikipedia.org\/wiki\/COVID-19_vaccine\">Innovio Pharmaceuticals,<\/a><\/li><li><a href=\"https:\/\/en.wikipedia.org\/wiki\/COVID-19_vaccine\">CanSino Biologics,<\/a><\/li><li><a href=\"https:\/\/en.wikipedia.org\/wiki\/COVID-19_vaccine\">Shenzhen Geno-Immune Medical Institute,<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Autophagy stimulator&nbsp;<\/strong>:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/en.wikipedia.org\/wiki\/Niclosamide\">Niclosamide<\/a>&nbsp;(<a href=\"https:\/\/en.wikipedia.org\/wiki\/Niclosamide\">inhaled<\/a>) or clinical trials by&nbsp;<a href=\"https:\/\/anatherapeutics.com\/our-plan\">ANA Therapeutics<\/a>,&nbsp;<a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.15.997254v1.full.pdf\">MK2206, and Spermidine<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Inhibiting Viral protein chaperone GRP78 and increasing autophagosome formation:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006295220304639\">AR-12<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Block viral entry at the endosomal stage by inhibiting phosphatidyl inositol 3,5 or 5 synthesis or effecting local zinc release from the fyve domain.<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>PIKfyve kinase inhibitor&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Apilimod\">apilimod<\/a><\/strong><\/li><\/ul>\n\n\n\n<h4 class=\"wp-block-heading\"><br><strong>Cysteine protease inhibitors MDL-28170, Z LVG CHN2, VBY-825, and ONO 5334<\/strong>. Effect endosomal processing\/entry of the virus into the cell. (Perhaps by inhibiting fusion peptide activating enzymes.<\/h4>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Inhibiting the Alternative Complement Pathway by inhibiting Factor D.<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Increasing cellular cholesterol biosynthesis with agents like amlodipine. possibly&nbsp;<a href=\"https:\/\/jcs.biologists.org\/content\/126\/15\/3462\">effecting ORP1L Cholesterol sensing, tethering, and endosomal transport.<\/a><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Inhibiting Endosomal Acidification , Recycling and\/or Viral Intra-Vesicular Transport\/Release to the Surface Membrane<\/strong>&nbsp;via effects on Retromer, PIKC3C3, and Commander.<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">I<strong>nhibiting Viral RNA transcription (<a href=\"https:\/\/www.genecards.org\/cgi-bin\/carddisp.pl?gene=SLTM\">SLTM<\/a><\/strong>, STEN<strong>), translation, ER viral protein processing, or Golgi viral protein Glycosylation\/DeGylcosylation\/<a href=\"https:\/\/www.pnas.org\/content\/early\/2020\/11\/04\/2013620117\">mannosidase<\/a>.<\/strong><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.nature.com\/articles\/s41564-020-00846-z\">Inhibiting Viral RNA \u2013 host protein interactions required for the viral life cycle. PPIA (cyclosporin A); ARP2(CK-548); ATP1A1(oubain); DDX3X() , mTORC1 phosphorylation of LARP1<\/a><\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">Stimulating intrinsic antiviral activity by DEAD-box RNA helicase&nbsp;<a href=\"https:\/\/www.news-medical.net\/news\/20201029\/Antiviral-inhibitor-DDX42-shows-broad-activity-against-Chikungunya-HIV-and-SARS-CoV-2.aspx\">DDX42<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/MX1\">Mx1<\/a>&nbsp;, CNBP, or LARP1<\/h3>\n\n\n\n<p> <strong>Nutritional&nbsp;<\/strong>: ( broccoli sprouts \u2013&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4587599\/\" target=\"_blank\" rel=\"noreferrer noopener\">sulforaphane<\/a>),&nbsp;<a href=\"https:\/\/www.sciencedaily.com\/releases\/2020\/05\/200507121353.htm\">Vitamin D,<\/a>&nbsp;Vitamin B6, Vitamin B1, Spermidine and Wellness Formula as prophylactics . <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fusion Peptide activating protease (cellular host\u2019s TMPRSS2) inhibitor: Camostat&nbsp;by Ono Pharmaceutical &nbsp;Innate or Adaptive Immune System Modulators Dexamethasone\u00a0for stage 4 or greater COVID-19 Infection (Patients requiring a ventilator or in ICU) Anti-inflammatory via agonist of the cortisol receptor. Nebulized interferon beta 1\u00a0enhances innate antiviral immunity but interferon alpha\u00a0increases ACE-2 receptor expression\u00a0and is an indicator of [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8281,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8696","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8696","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/comments?post=8696"}],"version-history":[{"count":0,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8696\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8281"}],"wp:attachment":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/media?parent=8696"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}