{"id":8691,"date":"2021-08-08T18:50:20","date_gmt":"2021-08-09T01:50:20","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=8691"},"modified":"2021-11-05T18:13:07","modified_gmt":"2021-11-06T01:13:07","slug":"experimental-viral-targeted-treatments","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/covid-19-treatments\/experimental-viral-targeted-treatments\/","title":{"rendered":"Experimental  Viral Targeted Treatments"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Experimental&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1359644620300416#bib0475\">Treatments<\/a><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Viral RNA polymerase (nsp12) replication\/transcription Enzyme inhibitors<\/strong>&nbsp;<strong>or g\/sg RNA terminators\/mutators:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/science.sciencemag.org\/content\/early\/2021\/06\/02\/science.abi5224?rss=1\">Tempol <\/a>&#8211;   Free radical removes the Fe<sub>4<\/sub>S<sub>4<\/sub> iron clusters in the NSP12 replicase and inhibits activity<\/li><li><a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1008489\">Pralatrexate<\/a><\/li><li><a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1008489\">Azithromycin<\/a><\/li><li>Purine Nucleotide AT-527 from&nbsp;<a href=\"https:\/\/ateapharma.com\/\">Atea Pharmaceuticals<\/a>&nbsp;.<\/li><li><a rel=\"noreferrer noopener\" href=\"https:\/\/news.yahoo.com\/russia-claims-promising-signs-early-142400549.html\" target=\"_blank\">Favipiravir<\/a>=?polymerase inhibitor (teratogenic and embryotoxic),<\/li><li><a rel=\"noreferrer noopener\" href=\"https:\/\/stm.sciencemag.org\/content\/early\/2020\/04\/03\/scitranslmed.abb5883\" target=\"_blank\">NHC (\u03b2-D-N<sup>4<\/sup>-hydroxycytidine-5\u2032-isopropyl ester) or prodrug EIDD-2801<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/results\/NCT04392219?term=NCT04392219&amp;draw=2&amp;rank=1\">Emory University&nbsp;<\/a>\u2013<a href=\"https:\/\/www.businesswire.com\/news\/home\/20200526005229\/en\/\">&nbsp;Ridgeback<\/a>&nbsp;+&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/s41564-020-00835-2\">Merk :MK-4482\/EIDD-2801<\/a>=mutator,<\/li><li><a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1001176\">Zinc=enzyme inhibitor(elongation + template binding inhibitor<\/a>),<\/li><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6594388\/\">Ribavirin<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354220302710?via%3Dihub\">Cidofovir, Abacavir, Valganciclovir\/Ganciclovir, Stavudine and Entecavir = terminators<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Spike protein <strong>Neutralization<\/strong>&nbsp;or Receptor Binding Blockade :<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><a rel=\"noreferrer noopener\" href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.03.11.987958v1\" target=\"_blank\">Monoclonal Antibod<\/a><\/strong>y 47D11,<a href=\"https:\/\/sorrentotherapeutics.com\/\">&nbsp;Sorrento Therapuetic\u2019s&nbsp;<\/a><a href=\"https:\/\/investors.sorrentotherapeutics.com\/news-releases\/news-release-details\/sorrento-and-mount-sinai-health-system-jointly-develop-covi\">Triple Antibody-COVI-SHIELD<\/a>,&nbsp;<a href=\"http:\/\/www.astrazeneca.com\/\">AstraZeneca<\/a>&nbsp;monoclonal antibody.&nbsp;<strong>Convalescent Serum<\/strong>,&nbsp;<strong>Phage capsules<\/strong>,&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.sciencedaily.com\/releases\/2020\/04\/200402144526.htm\" target=\"_blank\"><strong>Human recombinant soluble ACE-2 protein<\/strong><\/a>,&nbsp;<a href=\"https:\/\/jvi.asm.org\/content\/84\/5\/2511#ref-22\">Giffithsin,<\/a>&nbsp;Anti-ACE-2 Antibodies, and ACE-2 binders that inhibit binding to the Spike protein (ie.&nbsp;<a href=\"https:\/\/medicalxpress.com\/news\/2020-12-clinical-histone-deacetylase-inhibitors-effective.html\">HDAC inhibitors panobinostat, givinostat hydrochloride monohydrate, CAY10603 and sirtino&nbsp;<\/a>)<\/li><li><a href=\"https:\/\/medicalxpress.com\/news\/2020-10-neuropilin-protein-covid-vaccine.html\">VEGF-A \/ Neuropilin Receptor Blockade or Post Receptor System Activation Inhibition<\/a>. via&nbsp;<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jm901755g\">EG00229(<\/a>involved in Pain signaling)<\/li><li><a href=\"https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(21)00335-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221003357%3Fshowall%3Dtrue\">Cepharanthine  binds Spike receptors and inhibits binding to ACE2 receptors<\/a><\/li><li><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fphar.2021.660490\/full\">Fenofibrate <\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Locking Viral Spike protein in the S conformation and inhibiting its binding to ACE-2 Receptors :<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/09\/18\/science.abd3255?rss=1\">Linoleic Acid<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Viral Main\/3CL Protease (nsp5) inhibitors:<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.fishersci.com\/us\/en\/catalog\/search\/products?keyword=ebselen\">Ebselen<\/a>,\u00a0<\/li><li><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2223-y_reference.pdf\" rel=\"noreferrer noopener\" target=\"_blank\">Disulfiram<\/a>\/Antabuse,\u00a0<\/li><li><a href=\"https:\/\/www.pfizer.com\/news\/hot-topics\/q_a_on_antivirals\" rel=\"noreferrer noopener\" target=\"_blank\">Pfizer\u2019s lead drug<\/a>&#8211; PF-07321332  shows 90 percent prevention of hospitalization when given with ritonavir<\/li><li><a href=\"https:\/\/science.sciencemag.org\/content\/early\/2020\/04\/21\/science.abb4489\">China\/Frontier Biotech\u2019s 11a compound.<\/a>,\u00a0<\/li><li><a href=\"https:\/\/www.nature.com\/articles\/s41422-020-0356-z\">Boceprevir, <\/a><\/li><li><a href=\"https:\/\/www.nature.com\/articles\/s41422-020-0356-z\">GC-376, <\/a><\/li><li><a href=\"https:\/\/www.nature.com\/articles\/s41422-020-0356-z\">calpain inhibitors II, XII<\/a>,\u00a0<a href=\"https:\/\/stm.sciencemag.org\/content\/early\/2020\/08\/03\/scitranslmed.abc5332\">6j,h\u00a0<\/a>.<\/li><li><a href=\"https:\/\/www.cell.com\/iscience\/fulltext\/S2589-0042(21)00335-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221003357%3Fshowall%3Dtrue\">Nelfinavir HIV protease inhibitor<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Viroporin (nsp4 and nsp6) inhibitors :<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/03079450601156083\">Lithium<\/a><\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Viral Papain Like protease (nsp 3)&nbsp;<\/strong>inhibitors :<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S0166354217306101?\">Disulfiram\/Antabuse<\/a>,&nbsp;<a href=\"https:\/\/www.pnas.org\/content\/pnas\/105\/42\/16119.full.pdf\">GRL0617<\/a>\/24,&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0166354214003660\">3k and 3j<\/a>, Hypericin, EGCG,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33672721\/\">InSilico Agents,<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33191083\/#&amp;gid=article-figures&amp;pid=fig-7-uid-7\">Compound 6,&nbsp;<\/a>7724772, 6577871, and Zinc<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Endonuclease N\/GN7 methyl transferase (nsp 14)&nbsp;<\/strong>inhibitors :<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.03.02.968388v1.full.pdf\">Endonuclease<\/a>&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1900129\/\">C&nbsp;<\/a>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1900129\/\">nsp15)<\/a>&nbsp;inhibitor<\/strong>s :<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04330586\">Ciclesonide<\/a>&nbsp;(also a steroid anti-inflammatory agent.)<\/li><\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7114383\/\">Viral Helicase<\/a>&nbsp;(nsp13) inhibitors<\/strong>:<\/h3>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7161877\/\">DTPMPA<\/a>&nbsp;and&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3421890\/\">SSYA10-00<\/a><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Experimental&nbsp;Treatments Viral RNA polymerase (nsp12) replication\/transcription Enzyme inhibitors&nbsp;or g\/sg RNA terminators\/mutators: Tempol &#8211; Free radical removes the Fe4S4 iron clusters in the NSP12 replicase and inhibits activity Pralatrexate Azithromycin Purine Nucleotide AT-527 from&nbsp;Atea Pharmaceuticals&nbsp;. Favipiravir=?polymerase inhibitor (teratogenic and embryotoxic), NHC (\u03b2-D-N4-hydroxycytidine-5\u2032-isopropyl ester) or prodrug EIDD-2801&nbsp;,&nbsp;Emory University&nbsp;\u2013&nbsp;Ridgeback&nbsp;+&nbsp;Merk :MK-4482\/EIDD-2801=mutator, Zinc=enzyme inhibitor(elongation + template binding inhibitor), Ribavirin&nbsp;,&nbsp;Cidofovir, Abacavir, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8281,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8691","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/comments?post=8691"}],"version-history":[{"count":0,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8691\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/8281"}],"wp:attachment":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/media?parent=8691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}