{"id":6288,"date":"2020-05-06T17:15:48","date_gmt":"2020-05-07T00:15:48","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=6288"},"modified":"2020-06-15T19:17:24","modified_gmt":"2020-06-16T02:17:24","slug":"hemolithin-precells-and-ur-enzymes","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/books\/origin-of-life-an-astrobiological-synthesis-of-physics-molecular-biology-and-geobiology\/the-physics-and-biochemistry-of-life\/hemolithin-precells-and-ur-enzymes\/","title":{"rendered":"Hemolithin, Precells, and Ur enzymes."},"content":{"rendered":"\n

\"\"<\/a><\/h3>\n\n\n\n

I hypothesize that hemolithins self aggregated into vesicles to form the first Precells with bipolar peptide based monolayer membranes. These vesicles were able to grow , divide, and harbor variations in metabolic networks.<\/a><\/h3>\n\n\n\n

Other Glycine\/Hydroxyglycine Peptides, Graphene , Buckyballs,  and metalo-corrin like complexes provided enzymatic surfaces which spurred metabolic network development inside early precells .<\/h3>\n\n\n\n

Molecular Clouds in interstellar Space may have been the location of early mixing of these agents to create higher order Replicons and Metabolic Networks.<\/h3>\n\n\n\n

Vitamin\/FeMo\/FeS\/FeO  Cofactors bound to Ur peptides during the early stages of precell formation.<\/h3>\n\n\n\n

<\/h3>\n\n\n\n

\"\"<\/a> …. \"\"<\/h3>\n\n\n\n

Aminolevulinic Acid (from glutamate, glut-tRNA, GtrR and NADPH followed by GsaM + Vitamin B6<\/a>) created Corrin like molecules that complexed with<\/a> with Iron forming heme, Magnesium forming chlorophyll, Cobalt froming Vitamin B12, and Nickel forming Cofactor F430<\/a>. These types of Metalo-Organic agents lead to enhanced metabolic functions and promoted Organic Molecule diversification. They also supported metabolic energy conversion (from oxidation-reduction reactions and free radicals). <\/h3>\n\n\n\n

I hypothesize that Beta electrons from radioactivity or perovskite crystals stimulated with  gamma rays, xrays, ultraviolet light, and visible light. was also utilized by the energy systems of the early precells.<\/a><\/h3>\n\n\n\n

Mixtures of Amino Acids, Carbohydrates, Lipids, Solutes, Nucleic Acids, and Cofactors evolved into  Metabolic Networks consisting of  GADV-Proteins<\/a>, PAHs<\/a>  , Peptide-RNA polymers <\/a>, or RNA onl<\/a>y networks . <\/h3>\n\n\n\n

Precells evolved within  Montmorillonite<\/a> Clay, Iron-Sulfur<\/a>,  and \/or Zinc precipitated environments on hydrothermal vents (on proto-earth , planetismals, or inside  cosmic spherules ) .<\/h3>\n\n\n\n

It is  unknown if the PreCells evolved from a  metabolism first<\/a> , replicon first<\/a> and\/or hybrid process<\/a> . I personally believe the metabolism first model is the most congruent with data showing spontaneous self assembly of TCA\/Krebs cycle like reaction networks.<\/h3>\n\n\n\n

<\/h3>\n\n\n\n

<\/a><\/h3>\n","protected":false},"excerpt":{"rendered":"

I hypothesize that hemolithins self aggregated into vesicles to form the first Precells with bipolar peptide based monolayer membranes. These vesicles were able to grow , divide, and harbor variations in metabolic networks. Other Glycine\/Hydroxyglycine Peptides, Graphene , Buckyballs,  and metalo-corrin like complexes provided enzymatic surfaces which spurred metabolic network development inside early precells . Molecular Clouds […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1363,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-6288","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/6288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/comments?post=6288"}],"version-history":[{"count":0,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/6288\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/1363"}],"wp:attachment":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/media?parent=6288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}