{"id":10988,"date":"2025-11-23T12:31:58","date_gmt":"2025-11-23T20:31:58","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=10988"},"modified":"2025-11-23T12:32:06","modified_gmt":"2025-11-23T20:32:06","slug":"eeg-and-evoked-potentials-in-preclinical-ad","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/home\/alzheimers\/alzheimers-disease-tests-under-development\/eeg-and-evoked-potentials-in-preclinical-ad\/","title":{"rendered":"EEG and Evoked Potentials in preClinical AD"},"content":{"rendered":"\n<p><a><strong>who is studying eeg patterns or evoked potential in pre clinical alzheimers disease?<\/strong><\/a><\/p>\n\n\n\n<p>Several major groups and cohorts are actively studying EEG and evoked\/event\u2011related potentials (ERPs) in preclinical Alzheimer\u2019s disease, mostly in amyloid\u2011PET\u2013characterized or familial\u2011risk populations. Below are some of the key players and study frameworks.<a><\/a><a href=\"#fn19\"><sup>[19]<\/sup><\/a><a><\/a><a href=\"#fn20\"><sup>[20]<\/sup><\/a><a><\/a><a href=\"#fn21\"><sup>[21]<\/sup><\/a><\/p>\n\n\n\n<p><a><strong>Major research cohorts<\/strong><\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>INSIGHT\u2011preAD (Paris, France): Single\u2011center cohort of ~300 cognitively normal older adults with amyloid PET, led by Bruno Dubois and colleagues at the Salp\u00eatri\u00e8re Hospital; Gaubert et al. have published high\u2011density resting\u2011state EEG work showing compensatory EEG changes across preclinical A\/T(N) stages.<a href=\"#fn20\"><sup>[20]<\/sup><\/a><a href=\"#fn22\"><sup>[22]<\/sup><\/a><\/li>\n\n\n\n<li>ADNI \/ EEG substudies: ADNI\u2011linked work has examined EEG markers of amyloid\u2013tau interaction and compensatory mechanisms in individuals at preclinical and prodromal stages.<a href=\"#fn21\"><sup>[21]<\/sup><\/a><\/li>\n<\/ul>\n\n\n\n<p><a><strong>Familial and genetic\u2011risk studies<\/strong><\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Familial AD mutation carriers: Studies of cortical ERPs in presymptomatic carriers of autosomal\u2011dominant AD mutations have been performed by groups working in large FAD kindreds, demonstrating ERP changes years before symptoms.<a href=\"#fn23\"><sup>[23]<\/sup><\/a><a href=\"#fn19\"><sup>[19]<\/sup><\/a><\/li>\n\n\n\n<li>APOE \u03b54 and family\u2011history cohorts: Classic ERP work in increased\u2011risk but cognitively normal adults (family history \u00b1 APOE \u03b54) has shown P3 and N2 latency changes consistent with preclinical AD physiology.<a href=\"#fn24\"><sup>[24]<\/sup><\/a><a href=\"#fn23\"><sup>[23]<\/sup><\/a><\/li>\n<\/ul>\n\n\n\n<p><a><strong>Recent EEG\/ERP methodology work<\/strong><\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Quantitative EEG and machine learning: Recent clinical\u2011neurophysiology papers use quantitative EEG and event\u2011related oscillations from working\u2011memory and other cognitive paradigms to classify preclinical AD or neurodegeneration in at\u2011risk but unimpaired individuals.<a href=\"#fn25\"><sup>[25]<\/sup><\/a><a href=\"#fn26\"><sup>[26]<\/sup><\/a><\/li>\n\n\n\n<li>ERP component reviews and N400 work: Contemporary reviews and experimental studies focus on P300, N400 and related components as sensitive markers of synaptic\/cognitive dysfunction in early or preclinical AD.<a href=\"#fn27\"><sup>[27]<\/sup><\/a><a href=\"#fn28\"><sup>[28]<\/sup><\/a><a href=\"#fn23\"><sup>[23]<\/sup><\/a><\/li>\n<\/ul>\n\n\n\n<p>If you tell what population (APOE4, SCD, FAD, amyloid\u2011PET\u2013positive normals) and paradigm (resting\u2011state, P300 oddball, N400 language, working memory) you care about, more targeted groups and PIs can be listed.<br><br><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.sciencealert.com\/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours\">https:\/\/www.sciencealert.com\/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours<\/a>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/science.slashdot.org\/story\/25\/10\/16\/0245204\/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours\">https:\/\/science.slashdot.org\/story\/25\/10\/16\/0245204\/new-alzheimers-treatment-clears-plaques-from-brains-of-mice-within-hours<\/a>\u00a0\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.yahoo.com\/news\/articles\/alzheimers-treatment-clears-plaques-brains-024934387.html\">https:\/\/www.yahoo.com\/news\/articles\/alzheimers-treatment-clears-plaques-brains-024934387.html<\/a>\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.newsweek.com\/alzheimers-disease-striking-reversal-mice-10834889\">https:\/\/www.newsweek.com\/alzheimers-disease-striking-reversal-mice-10834889<\/a>\u00a0\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencemediacentre.org\/expert-reaction-to-study-of-amyloid-%CE%B2-clearance-in-a-mouse-model-of-alzheimers-disease\/\">https:\/\/www.sciencemediacentre.org\/expert-reaction-to-study-of-amyloid-\u03b2-clearance-in-a-mouse-model-of-alzheimers-disease\/<\/a>\u00a0\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41392-025-02426-1\">https:\/\/www.nature.com\/articles\/s41392-025-02426-1<\/a>\u00a0\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/www.psypost.org\/nanoparticle-therapy-restores-brain-function-in-mice-with-alzheimers-disease\/\">https:\/\/www.psypost.org\/nanoparticle-therapy-restores-brain-function-in-mice-with-alzheimers-disease\/<\/a>\u00a0<\/li>\n\n\n\n<li><a href=\"https:\/\/rupress.org\/jem\/article\/213\/5\/677\/42120\/Rapid-in-vivo-measurement-of-amyloid-reveals\">https:\/\/rupress.org\/jem\/article\/213\/5\/677\/42120\/Rapid-in-vivo-measurement-of-amyloid-reveals<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3972013\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3972013\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3651582\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3651582\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC544607\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC544607\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.facebook.com\/ScienceNaturePage\/posts\/new-alzheimers-treatment-successfully-cleared-plaques-from-the-brains-of-mice-wi\/1355474719366727\/\">https:\/\/www.facebook.com\/ScienceNaturePage\/posts\/new-alzheimers-treatment-successfully-cleared-plaques-from-the-brains-of-mice-wi\/1355474719366727\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.linkedin.com\/posts\/dato-capt-dr-mahesan-subramaniam-3080a4115_new-alzheimers-treatment-successfully-cleared-activity-7385593954119032832-usk5\">https:\/\/www.linkedin.com\/posts\/dato-capt-dr-mahesan-subramaniam-3080a4115_new-alzheimers-treatment-successfully-cleared-activity-7385593954119032832-usk5<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371%2Fjournal.pone.0010549\">https:\/\/journals.plos.org\/plosone\/article?id=10.1371%2Fjournal.pone.0010549<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0028390814000306\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0028390814000306<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/digitalcommons.wustl.edu\/cgi\/viewcontent.cgi?article=7099&amp;context=open_access_pubs\">https:\/\/digitalcommons.wustl.edu\/cgi\/viewcontent.cgi?article=7099&amp;context=open_access_pubs<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.instagram.com\/p\/DP-_H-vlCY7\/\">https:\/\/www.instagram.com\/p\/DP-_H-vlCY7\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3074951\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3074951\/<\/a><\/li>\n\n\n\n<li><a id=\"fn19\"><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2788802\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2788802\/<\/a>\u00a0<\/li>\n\n\n\n<li><a id=\"fn20\"><\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31211359\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31211359\/<\/a>\u00a0<\/li>\n\n\n\n<li><a id=\"fn21\"><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7475697\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7475697\/<\/a>\u00a0<\/li>\n\n\n\n<li><a id=\"fn22\"><\/a><a href=\"https:\/\/adni.loni.usc.edu\/adni-publications\/Gaubert-2019-EEG%20evidence%20of%20compensatory%20mech.pdf\">https:\/\/adni.loni.usc.edu\/adni-publications\/Gaubert-2019-EEG evidence of compensatory mech.pdf<\/a><\/li>\n\n\n\n<li><a id=\"fn23\"><\/a><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3765089\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3765089\/<\/a>\u00a0\u00a0<\/li>\n\n\n\n<li><a id=\"fn24\"><\/a><a href=\"https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/775565\">https:\/\/jamanetwork.com\/journals\/jamaneurology\/fullarticle\/775565<\/a><\/li>\n\n\n\n<li><a id=\"fn25\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388245724003365\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1388245724003365<\/a><\/li>\n\n\n\n<li><a id=\"fn26\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0197458021001470\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0197458021001470<\/a><\/li>\n\n\n\n<li><a id=\"fn27\"><\/a><a href=\"https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2025.1513049\/full\">https:\/\/www.frontiersin.org\/journals\/aging-neuroscience\/articles\/10.3389\/fnagi.2025.1513049\/full<\/a><\/li>\n\n\n\n<li><a id=\"fn28\"><\/a><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0167876024001685\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0167876024001685<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full\/10.1016\/j.jalz.2012.05.1953\">https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full\/10.1016\/j.jalz.2012.05.1953<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.0b013e318227b1b0\">https:\/\/www.neurology.org\/doi\/10.1212\/WNL.0b013e318227b1b0<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3328927\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3328927\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.frontiersin.org\/journals\/global-womens-health\/articles\/10.3389\/fgwh.2025.1531062\/full\">https:\/\/www.frontiersin.org\/journals\/global-womens-health\/articles\/10.3389\/fgwh.2025.1531062\/full<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.neurology.org\/doi\/10.1212\/WNL.98.18_supplement.2242\">https:\/\/www.neurology.org\/doi\/10.1212\/WNL.98.18_supplement.2242<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12119584\/\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12119584\/<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352872915000706\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2352872915000706<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT02843529\">https:\/\/clinicaltrials.gov\/study\/NCT02843529<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/clinicaltrials.gov\/study\/NCT03644043\">https:\/\/clinicaltrials.gov\/study\/NCT03644043<\/a><\/li>\n<\/ol>\n\n\n\n<p><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10076640\/\">Prefrontal EEG slowing, synchronization, and ERP peak latency in association with predementia stages of Alzheimer\u2019s disease &#8211; PMC<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>who is studying eeg patterns or evoked potential in pre clinical alzheimers disease? Several major groups and cohorts are actively studying EEG and evoked\/event\u2011related potentials (ERPs) in preclinical Alzheimer\u2019s disease, mostly in amyloid\u2011PET\u2013characterized or familial\u2011risk populations. Below are some of the key players and study frameworks.[19][20][21] Major research cohorts Familial and genetic\u2011risk studies Recent EEG\/ERP [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":10457,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10988","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/10988","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/comments?post=10988"}],"version-history":[{"count":1,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/10988\/revisions"}],"predecessor-version":[{"id":10989,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/10988\/revisions\/10989"}],"up":[{"embeddable":true,"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/pages\/10457"}],"wp:attachment":[{"href":"https:\/\/www.telemedical.com\/wordpress\/wp-json\/wp\/v2\/media?parent=10988"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}