{"id":10087,"date":"2025-08-06T18:04:44","date_gmt":"2025-08-07T01:04:44","guid":{"rendered":"https:\/\/www.telemedical.com\/wordpress\/?page_id=10087"},"modified":"2025-10-19T20:16:38","modified_gmt":"2025-10-20T03:16:38","slug":"polyrisk-analysis-for-alzheimers","status":"publish","type":"page","link":"https:\/\/www.telemedical.com\/wordpress\/home\/alzheimers\/polyrisk-analysis-for-alzheimers\/","title":{"rendered":"Poly genetic risk factor analysis for Alzheimer Disease"},"content":{"rendered":"\n

Order a poly genetic risk factor analysis from <\/a>Mynucleus<\/a> as part of complete genetic sequencing<\/h2>\n\n\n\n

The selected 31 SNPs, their closest genes, their log hazard ratio estimates, and their conditional p-<\/em>values in the final joint model, after controlling for effects of gender and APOE<\/em> variants.<\/h3>\n\n\n\n
SNP<\/th>Chromosome<\/th>Position<\/th>Gene<\/th>\u03b2 (log HR)<\/th>Conditional p-<\/em>value in \u2212log10<\/sub><\/th><\/tr><\/thead>
\u03b52 allele<\/td>19<\/td><\/td>APOE<\/em><\/td>\u22120.47<\/td>>15.0<\/td><\/tr>
\u03b54 allele<\/td>19<\/td><\/td>APOE<\/em><\/td>1.03<\/td>>20.0<\/td><\/tr>
rs4266886<\/td>1<\/td>207685786<\/td>CR1<\/em><\/td>\u22120.09<\/td>2.7<\/td><\/tr>
rs61822977<\/td>1<\/td>207796065<\/td>CR1<\/em><\/td>\u22120.08<\/td>2.8<\/td><\/tr>
rs6733839<\/td>2<\/td>127892810<\/td>BIN1<\/em><\/td>\u22120.15<\/td>10.5<\/td><\/tr>
rs10202748<\/td>2<\/td>234003117<\/td>INPP5D<\/em><\/td>\u22120.06<\/td>2.1<\/td><\/tr>
rs115124923<\/td>6<\/td>32510482<\/td>HLA-DRB5<\/em><\/td>0.17<\/td>7.4<\/td><\/tr>
rs115675626<\/td>6<\/td>32669833<\/td>HLA-DQB1<\/em><\/td>\u22120.11<\/td>3.2<\/td><\/tr>
rs1109581<\/td>6<\/td>47678182<\/td>GPR115<\/em><\/td>\u22120.07<\/td>2.6<\/td><\/tr>
rs17265593<\/td>7<\/td>37619922<\/td>BC043356<\/a><\/em><\/td>\u22120.23<\/td>3.6<\/td><\/tr>
rs2597283<\/td>7<\/td>37690507<\/td>BC043356<\/a><\/em><\/td>0.28<\/td>4.7<\/td><\/tr>
rs1476679<\/td>7<\/td>100004446<\/td>ZCWPW1<\/em><\/td>0.11<\/td>4.9<\/td><\/tr>
rs78571833<\/td>7<\/td>143122924<\/td>AL833583<\/a><\/em><\/td>0.14<\/td>3.8<\/td><\/tr>
rs12679874<\/td>8<\/td>27230819<\/td>PTK2B<\/em><\/td>\u22120.09<\/td>4.2<\/td><\/tr>
rs2741342<\/td>8<\/td>27330096<\/td>CHRNA2<\/em><\/td>0.09<\/td>2.9<\/td><\/tr>
rs7831810<\/td>8<\/td>27430506<\/td>CLU<\/em><\/td>0.09<\/td>3.0<\/td><\/tr>
rs1532277<\/td>8<\/td>27466181<\/td>CLU<\/em><\/td>0.21<\/td>8.3<\/td><\/tr>
rs9331888<\/td>8<\/td>27468862<\/td>CLU<\/em><\/td>0.16<\/td>5.1<\/td><\/tr>
rs7920721<\/td>10<\/td>11720308<\/td>CR595071<\/a><\/em><\/td>\u22120.07<\/td>2.9<\/td><\/tr>
rs3740688<\/td>11<\/td>47380340<\/td>SPI1<\/em><\/td>0.07<\/td>2.8<\/td><\/tr>
rs7116190<\/td>11<\/td>59964992<\/td>MS4A6A<\/em><\/td>0.08<\/td>3.9<\/td><\/tr>
rs526904<\/td>11<\/td>85811364<\/td>PICALM<\/em><\/td>\u22120.20<\/td>2.3<\/td><\/tr>
rs543293<\/td>11<\/td>85820077<\/td>PICALM<\/em><\/td>0.30<\/td>4.2<\/td><\/tr>
rs11218343<\/td>11<\/td>121435587<\/td>SORL1<\/em><\/td>0.18<\/td>2.8<\/td><\/tr>
rs6572869<\/td>14<\/td>53353454<\/td>FERMT2<\/em><\/td>\u22120.11<\/td>3.0<\/td><\/tr>
rs12590273<\/td>14<\/td>92934120<\/td>SLC24A4<\/em><\/td>0.10<\/td>3.5<\/td><\/tr>
rs7145100<\/td>14<\/td>107160690<\/td>abParts<\/em><\/td>0.08<\/td>2.0<\/td><\/tr>
rs74615166<\/td>15<\/td>64725490<\/td>TRIP4<\/em><\/td>\u22120.23<\/td>3.1<\/td><\/tr>
rs2526378<\/td>17<\/td>56404349<\/td>BZRAP1<\/em><\/td>0.09<\/td>4.9<\/td><\/tr>
rs117481827<\/td>19<\/td>1021627<\/td>C19orf6<\/em><\/td>\u22120.09<\/td>2.5<\/td><\/tr>
rs7408475<\/td>19<\/td>1050130<\/td>ABCA7<\/em><\/td>0.18<\/td>4.3<\/td><\/tr>
rs3752246<\/td>19<\/td>1056492<\/td>ABCA7<\/em><\/td>\u22120.25<\/td>8.4<\/td><\/tr>
rs7274581<\/td>20<\/td>55018260<\/td>CASS4<\/em><\/td>0.10<\/td>2.1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score – PMC<\/a><\/p>\n\n\n\n

Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease | Scientific Reports<\/a><\/p>\n\n\n\n

Integrated healthy lifestyle even in late-life mitigates cognitive decline risk across varied genetic susceptibility – PubMed<\/a><\/p>\n\n\n\n

Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life – PubMed<\/a><\/p>\n\n\n\n

Assessing polyomic risk to predict Alzheimer’s disease using a machine learning model – PubMed<\/a><\/p>\n\n\n\n