Wellness Center : Exercise and Fitness: Fat Weight Loss Clinic :
Fat Reducing Formulas and Medications
Food and Beverage Replacements (Providing controlled caloric intake)
Ambromeal : A Personalized Circadian Nutrition Formula
Other Products
Appetite Suppressants that reduce meal size and meal frequency.
(ie. Anorexogenics/Induce satiety or reduce hunger )

Sympathetic and Mimetic Agents : Norepinephrine, Epinephrine, Methamphetamine, Phentermine, Didrex, Tenuate , Bontril , ephedrine

 Neurotransmitter Reuptake Inhibitor (ie Serotonin) : Meridia

MC4 Receptor Agonists :

alpha-MSH

Orexin inhibitors
Hoodia Cactus Ingredient : P57 Cannabanoid CB1 Receptor Antagonists
Glucose dietary oleate or tiolein and oleylethanolamide via CCK and capsaicin sensitive peripheral sensory neurons
antagonism of ghrelin's (hunger hormone) activation of the NPY/Agouti Related Peptide Orexigenic Response Apo A-IV from Chylomicrons via the hypothalamus
Peptide YY Ciliary Neurotrophic Factor
Melanin Concentrating Hormone Reduction or MCHR1 Antagonism Leptin from Subcutaneous Adipocytes
Regulators of Adipocyte Triglyceride Deposition and Fatty Acid Release

alpha-MSH (melanocyte stimulating hormone) inhibits fat deposition

norepinephrine and epinephrine from the sympathetic nerves and blood stream inhibit fat deposition.(this effect is enhanced by estrogen ) These sympathetic agents also stimulate fatty acid release from adipocytes via stimulation of hormone sensitive lipase.

cortisol stimulates fat deposition in visceral and intrabdominal areas but has been reported to inhibit lipogenesis in subcutaneous distributions. Children with increased cortisol production due to increased 17 keto steroid dehydrogenase activity are obese.

progesterone stimulates fat deposition in subcutaneous adipocytes.

insulin stimulates fat deposition in adipocytes via hormone sensitive lipase inhibition and acetyl CoA Carboxylase stimulation. Therefore, reducing insulin release is a goal in most fat weight loss plans.

estrogen and testosterone regulate the deposition and distribution of fat in intrabdominal adipocytes, subcutaneous adipocytes, and visceral organs in a complex and integrated way.

TNF-alpha stimulates lipolysis in adipoctyes and their reversion to the preadipocyte phenotype

The human albumin protein helps carry released fatty acids away from adipocytes and towards their place of disposition. Therefore, increased levels of this important blood protein (which is produced by the liver) should help in removal of fat from adipocyte storage.

FOX-A2 protein -blocks preadipocyte differentiation and prevents mature adipocytes from continuing to build fat.

C3a-desArg/Acylation Stimulation Protein binds to the C5L2 Receptor on Fat cells (ie. adipocytes) and stimulates fat storage. Potential inhibition of this system could prevent fat accumulation.

Metabolic Stimulants

(Increase oxidation of fatty acids and degradation of glycerol)
  • Cold temperatures
  • Beta 3 adrenergic receptor agonists : ( Phentermine , Ephedrine)
  • Beta Thyroid Hormone Receptor Agonists
  • Human Growth Hormone and hGH Secretion Enhancers
  • UCP2 protein (Uncoupling Protein 2)
  • PPARgamma Agonists
  • ACRP30/Adiponectin/AdipoQ (also inhibits hepatic gluconeogenesis)
  • Melanin Concentrating Hormone Reduction or MCHR1 Antagonism
    		•
    Fat Substitutes
    Olestra
    Cholorectic

    CCK (Stimulates Gallbladder contraction and increased bile output)

    Artichoke extract ingredients : cynara
    Inhibitors of Intestinal Fat Absorption
    Lipase Inhibitor : Xenical
    Fat, bile acid, and cholesterol binding fibers/resins: Chitosan, B-Glucan
    Multiple or Unknown Mechanisms of Action

    CLA Conjugated Linoleic Acid is a mixture of isomers of a derivative of linoleic acid (9cis 11trans and 10trans 12cis) The isomers have different effects but the 10trans 12cis is reported to increase prostaglandin E1delta 9 production, stimulate hGH release, inhibit cortisol production, and directly kill adipoctyes. These effects may all result in increased lean body mass and decreased body fat .

    Myostatin Inhibitors-Reduce Lipogenesis and increase Musculogenesis

    References: Obesity Gene Map