Cell therapy for HIV

Cellular ImmunoTherapy for HIV Cure

1. November 13 2008 : A Potential proof of concept HIV Cure : Bone Marrow Stem Cell Tranplant from a CCR5 double deletion mutant to a patient undergoing complete bone marrow ablation for leukemia along with "graft versus host disease" prevention therapy. (20 months without evidence of HIV in his tissues. Confirmatory studies pending. )

2. Examples of Adoptive Immunotherapy in Humans:

a. Adoptive Cellular therapy using CMV specific T killer cells for the prevention of CMV pneumonia in immunosuppresed organ transplant patients

b Adoptive Cellular Immunotherapy of EBV lymphoproliferative disorder..

c. Cellular Immunotherapy for metastatic melanoma.

d. Cellular Immunotherapy for gliomas

3. Examples of Adpotive Immunotherapy in Animal Models:

a. CD4 and CD8 T Cell Expansions in Mice