Primate and Human Evolution via Infectious Speciation Events

Evidence of common ancestry ERVs (video)

Haplorrhini (extinct omomyids) and Strepsirrhini ("wet-nosed" primates- lemurs and lorises and extinct adapids), parted ways about 63 million years ago (mya).

Catarrhines evolved from Haplorrhines about 58 million years ago

Eosimias 42-45 Million Years Ago-- may be Earliest Catarrhine -

Marmosets -

Tarsiers -

-

Maccaca--

Gibbons

Proconsul --25 to 5 million years ago

Chimpanze--

Ardipithecus Kadaba 5.6 MYA

Ardipithecus Ramidus 4.4 MYA

Austrolopithecus Anamensis 4.0 MYA

Australopithecus Afarensis 3.9 - 2.9 MYA (LUCY)

Australopithecus Africanus 2.85-2.0 MYA

Australopithecus Sediba 1.97 MYA

Homo Habilis

Homo Ergaster

Homo Erectus 1.8 MYA

Homo Floresiensis ?

Homo Neanderthal 500K YA

Homo Denisovan 500K YA

Homo Sapiens 200K YA

Endogenous Retroviral Integrations in relation to Primate Evolutionary Events

1. HERV M integration 55 million years ago

2. XA34 ERV-9 like integration into the germ line 40-45 million years ago

3. Crystal structure of a pivotal domain of human syncytin-2, a 40 million years old endogenous retrovirus fusogenic envelope gene captured by primates.
Renard M, Varela PF, Letzelter C, Duquerroy S, Rey FA, Heidmann T.

4. HERV K family integrations 39 million years ago or 28 million years ago

5. Death and Resurrection of the Human IRGM Gene via an ERV 9 insertion event about 25 million years ago

6. HERV-K integrations 14 to 19 million years ago
7. The Solitary Long Terminal Repeats of ERV-9 Endogenous Retrovirus Are Conserved during Primate Evolution and Possess Enhancer Activities in Embryonic and Hematopoietic Cell (15-18 million ya)

8. Endogenous retrovirus drives hitherto unknown proapoptotic p63 isoforms in the male germ line of humans and great apes 15 million years ago

 

9. ERV 9 subfamily XII insertions 10-6 million years Ago during the time of the split between Humans and Chimpanzees

10. HERV W LTR family proliferation during the past 2-5 million years

11. Divergent patterns of recent retroviral integrations in the human and chimpanzee genomes: probable transmissions between other primates and chimpanzees.
Jern P, Sperber GO, Blomberg J.

 

Classes of Retroviruses

Taxonomy of ERV 9 and other retroviruses

Identification, phylogeny, and evolution of retroviral elements based on their envelope genes.

The gene of retroviral origin Syncytin 1 is specific to hominoids and is inactive in Old World monkeys.

Virolution